一、基本信息

尚松安，男，1988年02月生。博士学位，研究生学历，副主任医师，博士后，硕士研究生导师（学术型）。江苏省医师协会放射医师分会青年委员会委员，江苏省医学会影像技术分会磁共振学组委员。主要研究神经退行性疾病、神经影像新技术、数据处理及分子影像。对于PET/MRI、MRI新技术的开发应用、神经影像数据分析等具备了丰富的经验。主持国家自然科学基金一项、扬州市科技计划项目（社会发展）一项，参与国家级及省市级科研项目多项。以第一作者共发表研究论文19篇，其中SCI 11篇（总影响因子58.55，JCR一区6篇、JCR二区5篇）、中华系列期刊5篇、核心期刊2篇，包括权威期刊《Communications Biology》（Nature系列子刊）、《Journal of Cerebral Blood Flow & Metabolism》、《Human Brain Mapping》、《European Radiology》、《Journal of Magnetic Resonance Imaging》、《American Journal of Neuroradiology》、《中华放射学杂志》等；研究成果多次入选国际会议发言和壁报展示；获得江苏省新技术引进二等奖一项。邮箱：shangsongan0601@163.com。

二、教育经历

2020.01-2023.01 南京医科大学-博士后

2016.09-2019.06中南大学-影像医学与核医学-博士研究生

2011.09-2014.06东南大学-影像医学与核医学-硕士研究生

三、研究方向

主要研究神经退行性疾病、神经影像新技术、数据处理及分子影像。对于PET/MRI、MRI新技术的开发应用、神经影像数据分析等具备了丰富的经验。

四、承担项目

1、2023.01-2025.12，国家自然科学基金资助项目“基于神经血管稳态理论的多维度影像表征研究帕金森病执行功能障碍的演变机制及早期预测”（82202120，30万元），主持。

2、2022.07-2024.06，扬州市重点研发项目“帕金森病执行功能障碍关联神经血管稳态损伤的机制研究及早期预测:基于多维度影像表征”（YZ2022071，6万元），主持。

3、2016.01-2019.12，国家自然科学基金资助项目“基因多态性调控的散发型帕金森病认知功能损害的磁共振脑网络成像研究”（81571652，69.6万元），参与。

4、2017.07-2019.07，江苏省“333工程”培养资金资助项目“基因多态性关联的系统性红斑狼疮脑病的静息态功能磁共振成像研究”（BRA2017154，资助20万元），参与。

5、2018.07-2020.06，扬州市重点研发项目“联合应用磁共振动脉自旋标记新技术对缺血性脑卒中患者脑动脉狭窄及脑血流灌注改变的精准化评估”(YZ2018059，5万元)，参与。

五、代表性论著

发表学术论文：

1、Shang S., Zhu S., Wu J., et al. Topological Disruption of High-Order Functional Networks in Cognitively Preserved Parkinson’s Disease.CNS Neurosci Ther2022, Epub ahead of print.[IF=7.035, JCRQ1]

2、Shang S, Ye J, Wu J, et al. Early Disturbance of Dynamic Synchronization and Neurovascular Coupling in Cognitively Normal Parkinson’s Disease.Journal of Cerebral Blood Flow & Metabolism,2022;42(9):1719-1731[IF=6.960, JCRQ1]

3、Shang S, Li D, Tian Y, et al. Hybrid PET-MRI for early detection of dopaminergic dysfunction and microstructural degradation involved in Parkinson’s disease.CommunicationsBiology, 2021; 4(1):1162[IF=6.548, JCRQ1]

4、Shang S, Zhang H, Feng Y, et al. Region-specific Neurovascular Decoupling Associated with Cognitive Decline in Parkinson's Disease.Frontiers in Aging Neuroscience, 2021; 13:770528[IF=5.702, JCRQ2]

5、Shang S, Wu J, Zhang H, et al. Motor asymmetry related cerebral perfusion patterns in Parkinson's disease: an arterial spin labeling study.Human brain mapping. 2021;42(2):298-309[IF=5.399, JCRQ1]

6、Shang S, Wang L, Ye J, et al. Can Hybrid Arterial Spin Labeling-Tagged Zero-Echo-Time Magnetic Resonance Angiography Be an Effective Candidate in the Evaluation of Intracranial Artery Diseases? A Clinical Feasibility Study.Journal of magnetic resonance imaging, 2021;54(3):938-949[IF=5.119, JCRQ1]

7、Shang S, Wu J, Chen Y, et al. Aberrant cerebral perfusion pattern in amnestic mild cognitive impairment and Parkinson’s disease with mild cognitive impairment: a comparative arterial spin labeling study.Quantitative Imaging in Medicine and Surgery,2021; 11(7):3082-3097[IF=4.630, JCRQ2]

8、Shang S, Chen YC, Zhang H, et al. Mapping the interactive effects of ApoE gene polymorphism on caudate functional connectivity in mild cognitive impairment associated with Parkinson’s disease.Frontiers in Neuroscience. 2020, 17;14:857[IF=5.152, JCRQ2]

9、Shang S, Ye J, Dou W, et al, Validation of zTE-MRA in the characterization of cerebrovascular diseases: a feasibility study,American journal of neuroradiology, 2019;40(9):1484-1490[IF=4.966, JCRQ2]

10、Shang S, Ye J, Luo X, et al, Follow-up assessment of coiled intracranial aneurysms using zTE MRA as compared with TOF MRA: a preliminary image quality study,European radiology, 2017, 27(10):4271-4280[IF=7.034, JCRQ1]

11、尚松安,叶靖，罗先富，等.静音MR血管成像在颅内动脉瘤诊断中的可行性研究,中华放射学杂志, 2020, 54(4):325-331

12、尚松安,叶靖,甄勇,等.静音MR血管成像在颅内动脉瘤弹簧圈介入栓塞术后随访中的作用,中华放射学杂志, 2016, 50(10):779-783

13、尚松安,陈宇辰,马占龙,等. MRI诊断血管再狭窄的价值以及采用MRI分子成像评价血管再狭窄的可行性,中华放射学杂志, 2016, 50(4):295-301

14、尚松安,马占龙,陈相汛,等.原肌球蛋白-4抗体靶向标记合成型血管平滑肌细胞MR体外成像的实验研究,中华放射学杂志, 2013, 47(12):1132-1138

15、尚松安,陈相汛,安艳丽,等.合成型血管平滑肌细胞的分离、培养及鉴定,中华实验外科杂志, 2013, 30(12):2563-2565

16、尚松安,马占龙,陈相汛,等.不同方法对血管平滑肌细胞表型特性影响的实验研究,中国心血管病研究, 2013, 11(10):794-797

17、尚松安,马占龙.血管平滑肌细胞与血管性病变发生的分子成像研究进展,国际医学放射学杂志, 2013, 36(5):460-463

会议论文：

1、Shang S,et al. Zero TE continuous ASL MRA in the characterization of cerebral aneurysm a feasibility study, 102nd Scientific Assembly and Annual Meeting of the Radiological Society of North America, Chicago, United States of America, 2016.11.27-2016.12.02

2、Shang S,et al. More accurate stenosis assessment in cerebral ischemia using zero TE ASL MRA as compared to TOF MRA, 102nd Scientific Assembly and Annual Meeting of the Radiological Society of North America, Chicago, United States of America, 2016.11.27-2016.12.2

3、Shang S,et al. Zero TE continuous ASL MRA in the characterization of cerebral aneurysm: a feasibility study, ISMRM 24th Annual Meeting, Singapore, Republic of Singapore, 2016.05.07-2016.05.13

4、Shang S,et al. Validation of zTE MRA in the characterization of cerebrovascular diseases: a feasibility study, ISMRM 27th Annual Meeting, Montréal, QC, Canada, 2019.05.11-2019.05.16

5、Shang S,et al. Association of ApoE gene polymorphism and caudate functional connectivity in mild cognitive impairment of Parkinson's disease , ISMRM 28th Annual Meeting, Virtual online, 2020.08.08-2020.08.14

6、Shang S,et al. Can hybrid ASL-tagged ZTE MRA be an effective candidate in the evaluation of intracranial artery diseases? A clinical feasibility study, ISMRM 28th Annual Meeting, Virtual online, 2020.08.08-2020.08.14

7、Shang S,et al. Aberrant cerebral perfusion pattern in amnestic mild cognitive impairment and Parkinson's disease with mild cognitive impairment, ISMRM 29th Annual Meeting, Virtual online, 2021.05.15-2021.05.20

8、Shang S,et al. Region-specific neurovascular decoupling associated with cognitive decline in Parkinson's disease, ISMRM 30th Annual Meeting, London, England, United Kingdom, 2022.05.07-2022.05.12

9、Shang S,et al. Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson's disease: an integrated MRI study, ISMRM 30th Annual Meeting, London, England, United Kingdom, 2022.05.07-2022.05.12

六、获奖情况

磁共振动脉自旋标记灌注成像在中枢神经系统疾病诊断中的临床应用,江苏省卫生计生委,江苏省医学新技术引进奖，二等奖，2017