
一、基本信息
路国涛,扬州大学医学部副主任、党委委员,主任医师,医学博士,博士生导师,邮箱:gtlu@yzu.edu.cn。
入选国家“万人计划”青年拔尖人才、江苏省杰出青年基金获得者,主持国家自然科学基金4项(含1项区域联合重点)。以第一作者或通讯作者(含共同)在Cell Rep Med(2023)、Gut(2019)、Mol Ther(2023,2024)、Metabolism(2023,2025)、Redox Biol(2023)、AdvSci(2025)、Am J Gastroenterol(2024)等杂志发表高水平论文40余篇。兼任全球胰腺内脂肪沉积研究联盟(GARIF)专家指导委员会首席成员(全球共4位,中国唯一)、中华医学会消化病分会胰腺学组副组长、中国医师协会胰腺病分会委员等。参与制定多项国际及国内临床诊疗指南或专家共识(共6部)。授权中国3项发明专利。
二、教育经历
2003.09—2011.06,北京大学,临床医学(八年制),博士
三、研究方向
①胰腺损伤修复创新靶点筛选鉴定、药物开发及临床研究(主要方向)
②肝脏/肠道损伤免疫代谢调控
③消化道肿瘤早诊早治
四、承担项目
1. 国自然区域联合重点,2026/01-2029/12,259万元,主持
2. 国自然面上项目,2023/01-2026/12,52万元,主持
3. 江苏省杰出青年基金项目,2024/09-2027/08,180万,主持
4. 国自然面上项目,2021/01-2024/12,54万元,主持
5. 国自然青年基金,NO. 81801970,2019/01-2021/12,22万元,主持
五、代表性论著
1. Lu G#, Han F#, Wang Y#, Yuan C#, Zhu Q, Xia T, Chen L, Dong X, Ding Y, Xiao W, Zhang Y, Pan J, Xu H, Chen W, Tu B, Li W, Wang F*, Gong W*, Hu L*. Src Reduces Neutrophil Extracellular Traps Generation and Resolves Acute Organ Damage.Adv Sci. 2025 Aug 26:e06028.
2. Che Z#, Cai M#, Dong X#, Yuan Y, Wang Y, Xiao L, Song Y, Zhong J, Luo P, Wang H,Lu G*, Sun Y*, Xiao J*. Angiotensinogen inhibition concurrently mitigates alcohol-associated hepatic and muscle injury,Metabolism,2025 Apr 29:169:156275.
3. Zhu Q#, Yuan C#, Wang D#, Tu B, Chen W, Dong X, Wu K, Tao L, Ding Y, Xiao W, Hu L*, Gong W*, Li Z*,Lu G*. The TRIM28/miR133a/CD47 axis acts as a potential therapeutic target in pancreatic necrosis by impairing efferocytosis.Mol Ther. 2024 Sep 4;32(9):3025-3041.
4. Gu M#, Zhang Y#, Lin Z, Hu X, Zhu Y, Xiao W, Jia X, Chen W,Lu G*, Gong W*. Decrease in UCP1 by sustained high lipid promotes NK cell necroptosis to exacerbate nonalcoholic liver fibrosis.Cell Death Dis. 2024 Jul 20;15(7):518.
5. Dong X#, Zhu Q#, Yuan C#, Wang Y#, Ma X, Shi X, Chen W, Dong Z, Chen L, Shen Q, Xu H, Ding Y, Gong W, Xiao W, Wang S*, Li W*,Lu G*. Associations of Intrapancreatic Fat Deposition with Incident Diseases of the Exocrine and Endocrine Pancreas: A UK Biobank Prospective Cohort Study.Am J Gastroenterol. 2024 Apr
6. Zhu Q#, Yuan C#, Dong X#, Wang Y#, Li B, Tu B, Chen W, Xu X, Gong W, Xiao W, Ding Y, Hu L*, Li W*,Lu G*. Bile acid metabolomics identifies chenodeoxycholic acid as a therapeutic agent for pancreatic necrosis.Cell Rep Med. 2023 Dec 19;4(12):101304.
7. Han F#, Ding ZF#, Shi XL#, Zhu QT, Shen QH, Xu XM, Zhang JX, Gong WJ, Xiao WM, Wang D, Chen WW*, Hu LH*,Lu GT*. Irisin inhibits neutrophil extracellular traps formation and protects against acute pancreatitis in mice.Redox Biol. 2023 Aug; 64:102787.
8. Yuan C#, Xu Y#,Lu G#, Hu Y, Mao W, Ke L, Tong Z, Xia Y, Ma S, Dong X, Xian X, Wu X, Liu G, Li B, Li W. AAV-mediated hepatic LPL expression ameliorates severe hypertriglyceridemia and acute pancreatitis in Gpihbp1 deficient mice and rats.Mol Ther. 2023 Nov 15:S1525-0016(23)00619-6.