一、基本信息

李国才，博士，教授，博士生导师。学士，武汉大学生命科学学院微生物学专业；硕士，中科院沈阳应用生态所微生物工程专业；博士，扬州大学转基因动物制药专业；访学学者，美国圣路易斯华盛顿大学医学院微生物学系。电子信箱：gcli@yzu.edu.cn。

二、研究方向

病原细菌耐药/毒力调控机制与诊断技术等。

三、承担项目

1. 国家自然科学基金面上项目，抗CRISPR蛋白抑制CRISPR-Cas系统介导鲍曼不动杆菌耐药和毒力演化机制研究（82373637），2024-2027，49万元，主持

2. 国家自然科学基金面上项目，CRISPR-Cas系统通过群体感应系统对鲍曼不动杆菌耐药性和毒力的协同抑制研究（82073611），2021-2024，55万，主持

四、代表性论著

1. Hao J, Lu F, Chen P, Ji C, Li N, Xu Y, Chen Y, Liu C, Hu J, Li G*. Characterization of blaOXA-542-mediated carbapenem resistance inAcinetobacter baumannii. J Antimicrob Chemother. 2025,80(10):2854-2861.

2. Guo T, Yang J, Zhou N, Sun X, Huan C, Lin T, Bao G,Hu J*, Li G*. Cas3 of type I-Fa CRISPR-Cas system upregulates bacterial biofilm formation and virulence inAcinetobacter baumannii. Commun Biol. 2025,8(1):750.

3. Zhang P, Hao J, Zhang Y, Su J, Sun G, Xie J,Hu J*, Li G*. Understanding the clinical and molecular epidemiological characteristics of carbapenem-resistantAcinetobacter baumanniiinfections within intensive care units of three teaching hospitals. Ann Clin Microbiol Antimicrob. 2025,24(1):2.

4. Guo T, Yang L, Zhou N, Wang Z, Huan C, Zhou J, Lin T, Bao G,Hu J*, Li G*.Subminimum Inhibitory Concentrations Tetracycline Antibiotics Induce Biofilm Formation in Minocycline-ResistantKlebsiella pneumoniaby Affecting Bacterial Physical and Chemical Properties and Associated Genes Expression. ACS Infect Dis. 2024, 10(8):2929-2938.

5. Guo T, Zhou N, Yang L, Wang Z, Huan C, Lin T, Bao G, Hu J,Li G*.Acinetobacter baumanniibiofilm was inhibited by tryptanthrin through disrupting its different stages and genes expression. iScience. 2024,27(6):109942.

6. Wang Y, Su J, Zhou Z, Yang J, Liu W, Zhang Y, Zhang P, Guo T,Li G*. Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline. Microbiol Spectr. 2023,11(3): e0470222.

7. Wang Y, Yang J, Sun X, Li M, Zhang P, Zhu Z, Jiao H, Guo T,Li G*. CRISPR-Cas inAcinetobacter baumanniiContributes to Antibiotic Susceptibility by Targeting Endogenous AbaI. Microbiol Spectr. 2022,10(4):e0082922.

8. Guo T, Li M, Sun X, Wang Y, Yang L, Jiao H,Li G*. Synergistic Activity of Capsaicin and Colistin Against Colistin-Resistant Acinetobacter baumannii: In Vitro/Vivo Efficacy and Mode of Action. Front Pharmacol. 2021, 12: 744494.

9. Guo T, Sun X, Yang J, Yang L, Li M, Wang Y, Jiao H,Li G*. Metformin reverse minocycline to inhibit minocycline-resistantAcinetobacter baumanniiby destroy the outer membrane and enhance membrane potential in vitro. BMC Microbiol. 2022,22(1):215.

10. 张鹏宇,李金月,郭停停,等.CRISPR-Cas1对鲍曼不动杆菌耐药性与毒力的抑制作用[J].微生物学报, 2025,65(02):671-682.