一、基本信息

郭停停，女，山东邹城人，副教授，博士，硕士生导师，基础医学院·公共卫生学院，邮箱ttguo1989@yzu.edu.cn。荣获扬州大学“科技先锋”、“最受学生欢迎的班主任”等称号。担任BMCMicrobiology等杂志审稿人。

二、研究方向

主要从事鲍曼不动杆菌耐药水平及其调控机制及抗菌新策略研究。（1）探究粘菌素耐药新机制；（2）筛选能抑制/协同抑制鲍曼不动杆菌的中草单体，为临床治疗提供新策略；（3）利用抗生素之间的交互敏感特性为临床治疗提供新策略。

三、承担项目

1、国家自然科学基金青年基金项目，“基于辣椒素与粘菌素联用探讨其对粘菌素耐药鲍曼不动杆菌的作用及其机制”，项目号：82002186，2021/01-2023/12，24万，结题，主持

2、江苏省高等学校自然科学研究，面上项目，“BfmR/BfmS对鲍曼不动杆菌耐药相关外排泵基因调控机制研究”，项目号：19KJB310002，2019/09-2021/06，5万，结题，主持

3、江苏省人兽共患病学重点实验室,江苏省人兽共患病学重点实验室开放课题, R2201,桑黄酮与粘菌素联用对多重耐药革兰氏阴性菌的作用及其机制, 2022-10至2024-12, 3万元,结题,主持

四、代表性论著

1、Guo T, Yang J, Zhou N, Sun X, Huan C, Lin T, Bao G, Hu J, Li G. Cas3 of type I-Fa CRISPR-Cas system upregulates bacterial biofilm formation and virulence in Acinetobacter baumannii. Commun Biol.2025May 14;8(1):750.

2、Tingting Guo; Na Zhou; Liying Yang; Zichen Wang; Changchao Huan; Tao Lin; Guangyu Bao;Jian Hu; Guocai Li ; Acinetobacter baumannii biofilm was inhibited by tryptanthrin throughdisrupting its different stages and genes expression, iScience ,2024, 27(6): 109942

3、Tingting Guo; Liying Yang; Na Zhou; Zichen Wang; Changchao Huan; Jun Zhou; Tao Lin;Guangyu Bao; Jian Hu; Guocai Li ; Subminimum Inhibitory Concentrations Tetracycline AntibioticsInduce Biofilm Formation in Minocycline-Resistant Klebsiella pneumonia by Affecting BacterialPhysical and Chemical Properties and Associated Genes Expression, ACS Infect Dis. ,2024, 10(8):2929-2938

4、Tingting Guo; Jie Yang; Xiaoli Sun; Yuhang Wang; Liying Yang; Guimei Kong; Hongmei Jiao;Guangyu Bao; Guocai Li ; Whole-Genome Analysis of Acinetobacter baumannii Strain AB43 Containinga Type I-Fb CRISPR-Cas System: Insights into the Relationship with Drug Resistance., Molecules ,

2022, 27(17)

5、Tingting Guo; Xiaoli Sun; Jie Yang; Liying Yang; Mengying Li; Yuhang Wang; Hongmei Jiao;Guocai Li ; Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacterbaumannii by destroy the outer membrane and enhance membrane potential in vitro,BMCMicrobiology,2022, 22(1)

6、Guo, T. T.; Shan,C. L.; Li, J.Y.; Feng, H. H.; Li, M. Y.; Zheng,W. H.; Jiang, Q. Q.; Chen, J. H.; J, H. M.; Li, G. C.; L, W. J.; B, G.Y. Correlation between antibiotic resistance and serum resistance in Acinetobacter baumannii. International Journal of Clinical and Experimental Medicine2019;12(8):9804-9814