刘晶晶

性别：女

出生日期：1990年12月1日

籍贯：江苏镇江

邮箱：jjliu0105@163.com

教育背景

1. 2013/09-2018/06   博士，功能纳米与软物质研究院，苏州大学，专业：化  学，导师：刘  庄 教授（杰青，长江学者）

2. 2009/09-2013/06   本科，材料与化学化工学部，苏州大学，专业：化学

   工作经历

3. 2021.12-至今 扬州大学医学院，校特聘教授

4. 2018/10-2021/11   博士后，化学与生物分子工程系，新加坡国立大学

   导师：刘 斌 教授（新加坡工程院院士，美国国家工程

   院院士，新加坡国立大学副校长）

   研究方向

   在多功能纳米生物材料领域从事交叉学科研究，重点聚焦于配位聚合物纳米材料和仿生纳米材料的生物医学应用，首次开发了配位聚合物纳米材料作为放疗增敏剂在肿瘤治疗中的应用，基于该材料结构和理化性质的多样性，针对肿瘤独特的微环境特征设计了多种智能响应体系，提高了肿瘤内药物富集，并通过与生物活性材料的复合，实现了对肿瘤微环境的改善，进一步提高了肿瘤治疗效果。同时，近年来也探索多功能纳米生物材料在非酒精性脂肪肝炎（non-alcoholic steatohepatitis，NASH）诊疗和肝癌预防中的应用。

   荣誉与奖励

5. 2022年，入选江苏省特聘教授

6. 国家自然科学基金委员会，青年科学基金项目，32201078，腔肠荧光素工程化血小板在肿瘤靶向自激发-光动力治疗中的应用与机制研究，2023-01-01至2025-12-31，30万元，在研，主持。

7. 新加坡国立大学，H-511-00-000028，用于非酒精性脂肪肝炎的纳米探针，2018-4-1至2023-3-31，200万新加坡元，在研，参与。

8. 国家自然科学基金委员会，青年科学基金项目，51803146，基于光敏化作用的水凝胶载体原位可控制备与光动力/免疫联合治疗研究，2019-01-01至2021-12-31，26万元，结题，参与。

9. 国家自然科学基金委员会，面上项目，81771885，神经干细胞膜修饰的多功能免疫-纳米复合物用于胶质瘤靶向诊断与融合治疗，2018-01-01至2021-12-31，60万元，结题，参与。

10. 国家自然科学基金委员会，国际(地区)合作与交流项目，51761145041，无机纳米反应器与仿生载体用于肿瘤放射治疗研究，2017-10-01至2020-09-30，199万元，结题，参与。

11. 国家自然科学基金委员会，面上项目，81671743，肿瘤相关巨噬细胞介导的脑胶质瘤术中实时多模态成像与光动力治疗，2017-01-01至2020-12-31，56万元，结题，参与。

12. 国家自然科学基金委员会，青年科学基金项目，81602181，GD2靶向温敏胶束联合治疗神经母细胞瘤及抑制耐药的机制研究，2017-01-01至2019-12-31，18万元，结题，参与。

    发表学术论文情况

    自2014年以来，在化学、材料以及生物医学等多种国际高水平期刊上发表了40余篇SCI学术论文。论文总他引次数：6800余次，H-index：36。2021年受邀在Frontiers in Biochemical Engineering发表Research Topic，并任客座编辑。

13. Liu, J.*; Liu, B.*, Material-Assisted Engineering of Organelles for Biomedical Applications. ACS Materials Letters 2023, 5, 36-51. (IF=11.17)

14. Liu, J.; Liu, B., Living cell-mediated in-situ polymerization for biomedical applications. Progress in Polymer Science 2022, 129, 101545 (IF=29.19)

15. Liu, J.; Hu, F.; Wu, M.; Tian, L.; Gong, F.; Zhong, X.; Chen, M; Liu, Z.; Liu, B., Bioorthogonal Coordination Polymer Nanoparticle with Aggregation-Induced Emission for Deep Tumor Penetrating Radio- and Radiodynamic Therapy. Advanced Materials 2021, 33, 2007888（IF=30.849）

16. Liu, J.; Wu, M.; Pan, Y.; Duan, Y.; Dong, Z.; Chao, Y.; Liu, Z.; Liu, B., Biodegradable Nanoscale Coordination Polymers for Targeted Tumor Combination Therapy with Oxidative Stress Amplification. Advanced Functional Materials 2020, 30 (13), 1908865.（IF=18.808）

17. Liu, J.; Liu, X.; Wu, M.; Qi, G.; Liu, B., Engineering Living Mitochondria with AIE Photosensitizer for Synergistic Cancer Cell Ablation. Nano Letters 2020, 20 (10), 7438-7445.（IF=11.189）

18. Liu, J.; Chen, Q.; Feng, L.; Liu, Z., Nanomedicine for tumor microenvironment modulation and cancer treatment enhancement. Nano Today 2018, 21, 55-73.（IF= 20.722高被引文章）

19. Liu, J.；Tian, L.；Zhang, R.；Dong, Z.；Wang, H.；Liu, Z., Collagenase-Encapsulated pH-Responsive Nanoscale Coordination Polymers for Tumor Microenvironment Modulation and Enhanced Photodynamic Nanomedicine. ACS Applied Materials & Interfaces 2018, 10 (50), 43493-43502. (IF=9.229)

20. Liu, J.; Yang, G.; Zhu, W.; Dong, Z.; Yang, Y.; Chao, Y.; Liu, Z., Light-controlled drug release from singlet-oxygen sensitive nanoscale coordination polymers enabling cancer combination therapy. Biomaterials 2017, 146, 40-48.（IF=12.479）

21. Liu, J.; Wang, H.; Yi, X.; Chao, Y.; Geng, Y.; Xu, L.; Yang, K.; Liu, Z., pH-Sensitive Dissociable Nanoscale Coordination Polymers with Drug Loading for Synergistically Enhanced Chemoradiotherapy. Advanced Functional Materials 2017, 27 (44), 1703832. （IF=18.808）

22. Liu, J.; Liu, K.; Feng, L.; Liu, Z.; Xu, L., Comparison of nanomedicine-based chemotherapy, photodynamic therapy and photothermal therapy using reduced graphene oxide for the model system. Biomaterials Science 2017, 5 (2), 331-340. （IF=6.843）

23. Liu, J.; Chen, Q.; Zhu, W.; Yi, X.; Yang, Y.; Dong, Z.; Liu, Z., Nanoscale-Coordination-Polymer-Shelled Manganese Dioxide Composite Nanoparticles: A Multistage Redox/pH/H2O2-Responsive Cancer Theranostic Nanoplatform. Advanced Functional Materials 2017, 27 (10), 1605926.（IF=18.808）

24. Hu, H.^#; Liu, J.^#; Yu, J.^#; Wang, X.; Zheng, H.; Xu, Y.; Chen, M.; Han, J.; Liu, Z.; Zhang, Q., Synthesis of Janus Au@periodic mesoporous organosilica (PMO) nanostructures with precisely controllable morphology: a seed-shape defined growth mechanism. Nanoscale 2017, 9 (14), 4826-4834.（IF=7.79）

25. Zhao, H.^#; Chao, Y.^#; Liu, J.^#; Huang, J.; Pan, J.; Guo, W.; Wu, J.; Sheng, M.; Yang, K.; Wang, J.; Liu, Z., Polydopamine Coated Single-Walled Carbon Nanotubes as a Versatile Platform with Radionuclide Labeling for Multimodal Tumor Imaging and Therapy. Theranostics 2016, 6 (11), 1833-1843.（IF=11.556）

26. Liu, J.; Yang, Y.; Zhu, W.; Yi, X.; Dong, Z.; Xu, X.; Chen, M.; Yang, K.; Lu, G.; Jiang, L.; Liu, Z., Nanoscale metal−organic frameworks for combined photodynamic & radiation therapy in cancer treatment. Biomaterials 2016, 97, 1-9.（IF=12.479高被引文章）

27. Liu, J.; Wang, C.; Wang, X.; Wang, X.; Cheng, L.; Li, Y.; Liu, Z., Mesoporous Silica Coated Single-Walled Carbon Nanotubes as a Multifunctional Light-Responsive Platform for Cancer Combination Therapy. Advanced Functional Materials 2015, 25 (3), 384-392.（IF=18.808）

28. Qi, G.; Liu, X.; Shi, L.; Wu, M.; Liu, J.; Liu, B., Enzyme-Mediated Intracellular Polymerization of AIEgens for Light-Up Tumor Localization and Theranostics. Advanced Materials 2022, 34, 2106885.

29. Wu, M.; Liu, X.; Chen, H.; Duan, Y.; Liu, J.; Pan, Y.; Liu, B., Activation of Pyroptosis by Membrane-Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation. Angewandte Chemie 2021, 133 (16), 9175-9180.

30. Wu, M.; Qi, G.; Liu, X.; Duan, Y.; Liu, J.; Liu, B., Bio-Orthogonal AIEgen for Specific Discrimination and Elimination of Bacterial Pathogens via Metabolic Engineering. Chemistry of Materials 2020, 32 (2), 858-865.

31. Zhu, W.; Yang, Y.; Jin, Q.; Chao, Y.; Tian, L.; Liu, J.; Dong, Z.; Liu, Z., Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy. Nano Research 2019, 12 (6), 1307-1312.

32. Wang, Y.; Wu, W.; Liu, J.; Manghnani, P. N.; Hu, F.; Ma, D.; Teh, C.; Wang, B.; Liu, B., Cancer-Cell-Activated Photodynamic Therapy Assisted by Cu(II)-Based Metal–Organic Framework. ACS Nano 2019, 13 (6), 6879-6890.

33. Yang, Z.; Chen, Q.; Chen, J.; Dong, Z.; Zhang, R.; Liu, J.; Liu, Z., Tumor-pH-Responsive Dissociable Albumin–Tamoxifen Nanocomplexes Enabling Efficient Tumor Penetration and Hypoxia Relief for Enhanced Cancer Photodynamic Therapy. Small 2018, 14 (49), 1803262.

34. Yang, Y.; Xu, L.; Zhu, W.; Feng, L.; Liu, J.; Chen, Q.; Dong, Z.; Zhao, J.; Liu, Z.; Chen, M., One-pot synthesis of pH-responsive charge-switchable PEGylated nanoscale coordination polymers for improved cancer therapy. Biomaterials 2018, 156, 121-133.

35. Wang, H.; Zhu, W.; Liu, J.; Dong, Z.; Liu, Z., pH-Responsive Nanoscale Covalent Organic Polymers as a Biodegradable Drug Carrier for Combined Photodynamic Chemotherapy of Cancer. ACS Applied Materials & Interfaces 2018, 10 (17), 14475-14482.

36. Wang, H.; Chao, Y.; Liu, J.; Zhu, W.; Wang, G.; Xu, L.; Liu, Z., Photosensitizer-crosslinked in-situ polymerization on catalase for tumor hypoxia modulation & enhanced photodynamic therapy. Biomaterials 2018, 181, 310-317.

37. Meng, Z.; Chao, Y.; Zhou, X.; Liang, C.; Liu, J.; Zhang, R.; Cheng, L.; Yang, K.; Pan, W.; Zhu, M.; Liu, Z., Near-Infrared-Triggered in Situ Gelation System for Repeatedly Enhanced Photothermal Brachytherapy with a Single Dose. ACS Nano 2018, 12 (9), 9412-9422.

38. Jin, Q.; Liu, J.; Zhu, W.; Dong, Z.; Liu, Z.; Cheng, L., Albumin-Assisted Synthesis of Ultrasmall FeS2 Nanodots for Imaging-Guided Photothermal Enhanced Photodynamic Therapy. ACS Applied Materials & Interfaces 2018, 10 (1), 332-340.

39. Dong, Z.; Feng, L.; Hao, Y.; Chen, M.; Gao, M.; Chao, Y.; Zhao, H.; Zhu, W.; Liu, J.; Liang, C.; Zhang, Q.; Liu, Z., Synthesis of Hollow Biomineralized CaCO3–Polydopamine Nanoparticles for Multimodal Imaging-Guided Cancer Photodynamic Therapy with Reduced Skin Photosensitivity. Journal of the American Chemical Society 2018, 140 (6), 2165-2178.

40. Zhao, J.; Yang, Y.; Han, X.; Liang, C.; Liu, J.; Song, X.; Ge, Z.; Liu, Z., Redox-Sensitive Nanoscale Coordination Polymers for Drug Delivery and Cancer Theranostics. ACS Applied Materials & Interfaces 2017, 9 (28), 23555-23563.

41. Yang, Y.; Chao, Y.; Liu, J.; Dong, Z.; He, W.; Zhang, R.; Yang, K.; Chen, M.; Liu, Z., Core-shell and co-doped nanoscale metal-organic particles (NMOPs) obtained via post-synthesis cation exchange for multimodal imaging and synergistic thermo-radiotherapy. NPG Asia Materials 2017, 9 (1), e344-e344.

42. Zhu, W.; Dong, Z.; Fu, T.; Liu, J.; Chen, Q.; Li, Y.; Zhu, R.; Xu, L.; Liu, Z., Modulation of Hypoxia in Solid Tumor Microenvironment with MnO2 Nanoparticles to Enhance Photodynamic Therapy. Advanced Functional Materials 2016, 26 (30), 5490-5498.

43. Yang, Y.; Liu, J.; Sun, X.; Feng, L.; Zhu, W.; Liu, Z.; Chen, M., Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures. Nano Research 2016, 9 (1), 139-148.

44. Yang, Y.; Liu, J.; Liang, C.; Feng, L.; Fu, T.; Dong, Z.; Chao, Y.; Li, Y.; Lu, G.; Chen, M.; Liu, Z., Nanoscale Metal–Organic Particles with Rapid Clearance for Magnetic Resonance Imaging-Guided Photothermal Therapy. ACS Nano 2016, 10 (2), 2774-2781.

45. Yang, G.; Sun, X.; Liu, J.; Feng, L.; Liu, Z., Light-Responsive, Singlet-Oxygen-Triggered On-Demand Drug Release from Photosensitizer-Doped Mesoporous Silica Nanorods for Cancer Combination Therapy. Advanced Functional Materials 2016, 26 (26), 4722-4732.

46. Yang, G.; Liu, J.; Wu, Y.; Feng, L.; Liu, Z., Near-infrared-light responsive nanoscale drug delivery systems for cancer treatment. Coordination Chemistry Reviews 2016, 320-321, 100-117.

47. Song, G.; Chen, Y.; Liang, C.; Yi, X.; Liu, J.; Sun, X.; Shen, S.; Yang, K.; Liu, Z., Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy. Advanced Materials 2016, 28 (33), 7143-7148.

48. Gong, H.; Chao, Y.; Xiang, J.; Han, X.; Song, G.; Feng, L.; Liu, J.; Yang, G.; Chen, Q.; Liu, Z., Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy. Nano Letters 2016, 16 (4), 2512-2521.

49. Chen, Q.; Feng, L.; Liu, J.; Zhu, W.; Dong, Z.; Wu, Y.; Liu, Z., Intelligent Albumin–MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy. Advanced Materials 2016, 28 (33), 7129-7136.

50. Chao, Y.; Wang, G.; Liang, C.; Yi, X.; Zhong, X.; Liu, J.; Gao, M.; Yang, K.; Cheng, L.; Liu, Z., Rhenium-188 Labeled Tungsten Disulfide Nanoflakes for Self-Sensitized, Near-Infrared Enhanced Radioisotope Therapy. Small 2016, 12 (29), 3967-3975.

51. Yang, G.; Gong, H.; Qian, X.; Tan, P.; Li, Z.; Liu, T.; Liu, J.; Li, Y.; Liu, Z., Mesoporous silica nanorods intrinsically doped with photosensitizers as a multifunctional drug carrier for combination therapy of cancer. Nano Research 2015, 8 (3), 751-764.

52. Cheng, L.; Liu, J.; Gu, X.; Gong, H.; Shi, X.; Liu, T.; Wang, C.; Wang, X.; Liu, G.; Xing, H.; Bu, W.; Sun, B.; Liu, Z., PEGylated WS2 Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual-Modal CT/Photoacoustic Imaging Guided Photothermal Therapy. Advanced Materials 2014, 26 (12), 1886-1893.

53. Cheng, L.; Gong, H.; Zhu, W.; Liu, J.; Wang, X.; Liu, G.; Liu, Z., PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy. Biomaterials 2014, 35 (37), 9844-9852.