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“医源论坛” 第69期
发布日期:2019-09-08浏览次数:字号:[ ]

 

题目:Single-atom Nanozymes

报告人: 董绍俊 院士

报告时间:2019912日上午10:30

报告地点:江阳路北校区19号楼 9楼报告厅

主办单位:医学院、转化医学研究院

个人简介:

董绍俊,分析化学家,中国科学院长春应用化学研究所研究员。19529月毕业于北京辅仁大学化学系, 1999年当选发展中国家科学院院士。荣获国家自然科学奖3项、院省部级成果奖11项,国际奖1项。研究方向:电化学及相关交叉学科领域如化学修饰电极,生物电化学及生物传感器,适配子及DNA;光谱电化学;微电极;纳米电化学等。发表论文1000多篇,论文被他引57000多次,H指数115。迄今连续3次跨13年入选汤森路透(Web of Science)全球高被引科学家。

Single-atom Nanozymes

Recent achievements in nanozymes have been developed rapidly. However, there remain formidable challenges facing nanozyme technologies in limited catalytic activity and complicated constitutions. Here, a new class of single-atom nanozymes with atomically dispersed enzyme-like active sites in nanomaterials has been discovered. With oxidase catalysis as a model reaction, both experimental studies and theoretical calculations revealed that the synthesized single atom nanozymes of FeN5 SA/CNF catalytically behaved like axial coordinated heme of oxidoreductases. The catalytic rate constant of FeN5 SA/CNF is 70 times greater than that of the commercial Pt/C. Meanwhile, FeN5 SA/CNF exhibited broad-spectrum bactericidal properties both in vitro and in vivo. The defined single-atom nanozymes provide a new perspective to the catalytic mechanism and rational design of nanozymes and exhibit great potential to become the next-generation nanozymes.

 

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